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Environ Pollut. 2014 Apr;187:130-5. doi: 10.1016/j.envpol.2014.01.004. Epub 2014 Jan 28.

Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age.

Author information

  • 1Federal University of Rio de Janeiro, Campus Macaé, CEP 27930-560 RJ, Brazil.
  • 2University of Brasília, Brasília, 70919-970 DF, Brasil.
  • 3University of Brasília, Brasília, 70919-970 DF, Brasil. Electronic address: jg.dorea@gmail.com.
  • 4Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, RJ, Brazil.
  • 5Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, CEP 21941-902 RJ, Brazil.

Abstract

We studied neurodevelopment in infants from two communities. Children living in the vicinity of tin-ore kilns and smelters - TOKS; n = 51) were compared to children from a fishing village (Itapuã; n = 45). Mean hair-Hg (HHg) concentrations were significantly higher in Itapuã children which received significantly (p = 0.0000001) less mean ethylmercury (88.6 μg) from Thimerosal-containing vaccines (TCV) than the TOKS children (120 μg). Breast-milk Pb concentrations were significantly higher in the TOKS mothers (p = 0.000017; 10.04 vs. 3.9 μg L(-1)). Bayley mental development index (MDI) and psychomotor development index (PDI) were statistically significant (respectively p < 0.0000001, p = 0.000007) lower for the TOKS children only at 24 months of age. Multivariate regression analysis showed that MDI was negatively affected by breast-milk Pb and by HHg. PDI was positively affected by breastfeeding and negatively affected by ethylmercury. Milestone achievements were negatively affected by breast-milk Pb (age of walking) and by HHg (age of talking).

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Breast-milk; Ethyl-mercury; Fish consumption; Hair; Lactation; Methyl-mercury; Pregnancy

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