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Nature. 1988 Jan 28;331(6154):315-9.

Purification and reconstitution of the calcium release channel from skeletal muscle.

Author information

1
Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599.

Abstract

The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.

PMID:
2448641
DOI:
10.1038/331315a0
[Indexed for MEDLINE]

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