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Cell. 2014 Jan 30;156(3):392-3. doi: 10.1016/j.cell.2014.01.030.

Golgi feels DNA's pain.

Author information

1
IFOM (Fondazione Istituto FIRC di Oncologia Molecolare), Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Milan 20122, Italy. Electronic address: marco.foiani@ifom.eu.
2
Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 771 15 Olomouc, Czech Republic. Electronic address: jb@cancer.dk.

Abstract

The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular transport through DNA-PK-mediated GOLPH3 phosphorylation, thereby linking the DNA damage response to Golgi regulation.

PMID:
24485446
DOI:
10.1016/j.cell.2014.01.030
[Indexed for MEDLINE]
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