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Trends Microbiol. 2014 Feb;22(2):49-52. doi: 10.1016/j.tim.2013.11.007.

Do we need a new vaccine to control the re-emergence of pertussis?

Author information

1
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: kingston.mills@tcd.ie.
2
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Abstract

Bordetella pertussis causes whooping cough and is re-emerging in developed countries despite widespread immunization with acellular pertussis vaccines (Pa), which are less effective than the whole cell vaccines that they replaced. Efficacy of Pa could be improved by switching from alum to alternative adjuvants that generate more potent cell mediated immunity.

KEYWORDS:

Bordetella pertussis; Th1 cell; adjuvant; cell mediated immunity; vaccine; whooping cough

PMID:
24485284
DOI:
10.1016/j.tim.2013.11.007
[Indexed for MEDLINE]
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