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Semin Nephrol. 2014 Jan;34(1):17-26. doi: 10.1016/j.semnephrol.2013.11.004. Epub 2013 Nov 21.

Autophagy in acute kidney injury.

Author information

1
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA.
2
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA. Electronic address: zdong@gru.edu.

Abstract

Acute kidney injury is a major kidney disease associated with poor clinical outcomes. The pathogenesis of acute kidney injury is multifactorial and is characterized by tubular cell injury and death. Recent studies have shown autophagy induction in proximal tubular cells during acute kidney injury. The regulatory mechanisms of tubular cell autophagy are poorly understood; however, some recent findings have set up a foundation for further investigation. Although autophagy may promote cell death under certain experimental conditions, pharmacologic and autophagy-related gene knockout studies have established a renoprotective role for autophagy in acute kidney injury. The mechanisms by which autophagy protects cells from injury and how, possibly, its pro-survival role switches to pro-death under certain conditions are discussed. Further research is expected to help us understand the regulatory network of tubular cell autophagy, define its precise roles in the specific context of acute kidney injury, and identify autophagy-targeting strategies for the prevention and treatment of acute kidney injury.

KEYWORDS:

Acute kidney injury; autophagy; cell death; cell survival

PMID:
24485026
PMCID:
PMC3984003
DOI:
10.1016/j.semnephrol.2013.11.004
[Indexed for MEDLINE]
Free PMC Article

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