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Curr Opin Biotechnol. 2014 Feb;25:51-9. doi: 10.1016/j.copbio.2013.08.004. Epub 2013 Sep 14.

Universal quantitative NMR analysis of complex natural samples.

Author information

1
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, College of Pharmacy, 833 S. Wood Street, Chicago, IL, United States.
2
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, College of Pharmacy, 833 S. Wood Street, Chicago, IL, United States. Electronic address: gfp@uic.edu.

Abstract

Nuclear Magnetic Resonance (NMR) is a universal and quantitative analytical technique. Being a unique structural tool, NMR also competes with metrological techniques for purity determination and reference material analysis. In pharmaceutical research, applications of quantitative NMR (qNMR) cover mostly the identification and quantification of drug and biological metabolites. Offering an unbiased view of the sample composition, and the possibility to simultaneously quantify multiple compounds, qNMR has become the method of choice for metabolomic studies and quality control of complex natural samples such as foods, plants or herbal remedies, and biofluids. In this regard, NMR-based metabolomic studies, dedicated to both the characterization of herbal remedies and clinical diagnosis, have increased considerably.

PMID:
24484881
PMCID:
PMC3912461
DOI:
10.1016/j.copbio.2013.08.004
[Indexed for MEDLINE]
Free PMC Article

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