Format

Send to

Choose Destination
Curr Opin Biotechnol. 2014 Feb;25:45-50. doi: 10.1016/j.copbio.2013.08.015. Epub 2013 Sep 17.

Human-on-chip for therapy development and fundamental science.

Author information

1
Department of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy; Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy.
2
Department of Industrial Engineering, University of Padova, Via Marzolo 9, 35131 Padova, Italy; Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy. Electronic address: nicola.elvassore@unipd.it.

Abstract

Organ-on-chip systems integrate microfluidic technology and living cells to study human physiology and pathophysiology. These human in vitro models are promising substitutes for animal testing, and their small scale enables precise control of culture conditions and high-throughput experiments, which would not be economically sustainable on a macroscopic level. Multiple sources of biological material are used in the development of organ-on-chips, from biopsies to stem cells. Each source has its own peculiarities and technical requirements for integration into microfluidic chips, and is suitable for specific applications. While a biopsy is the tissue of choice for the biomimetic response to ageing, induced pluripotent stem cells hold great promise for the study of genetic-related disease pathogenesis, and primary cultures can fill the gap.

PMID:
24484880
DOI:
10.1016/j.copbio.2013.08.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center