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Curr Opin Biotechnol. 2014 Feb;25:39-44. doi: 10.1016/j.copbio.2013.08.010. Epub 2013 Sep 13.

Use of in vitro bioassays for assessing botanicals.

Author information

1
R&D Centre, Natural Remedies Pvt. Ltd., Plot 5B, Veerasandra Industrial Area, Electronic City PO, Hosur Road, Bangalore 560 100, Karnataka, India. Electronic address: amit@naturalremedy.com.
2
R&D Centre, Natural Remedies Pvt. Ltd., Plot 5B, Veerasandra Industrial Area, Electronic City PO, Hosur Road, Bangalore 560 100, Karnataka, India.

Abstract

In vitro bio assays can play a vital role in evaluating botanicals ranging from comparative screening, interaction studies, bio-activity guided fractionation, biological characterization, assisting in stability studies to studying mechanism of actions. In this review, we present some challenges and common pitfalls of using bioassays for assessing botanicals including guidance to overcome them. The overall objective of this review is to improve the success of botanicals products by incorporating robust bioassays during various stages of research and development.

PMID:
24484879
DOI:
10.1016/j.copbio.2013.08.010
[Indexed for MEDLINE]

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