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Radiology. 2014 Jun;271(3):695-702. doi: 10.1148/radiol.13122671. Epub 2014 Jan 27.

MR imaging-guided electrophysiological ablation studies in humans with passive catheter tracking: initial results.

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From the Departments of Radiology (M. Grothoff, L.L., C.L., J.H., L.H., M. Gutberlet), Electrophysiology (C.P., C.E., T.G., G.H., P.S.), and Obstetrics (J.H.), University of Leipzig Heart Center, Struempellstr 34, 04289 Leipzig, Germany; Imricor Medical Systems, Burnsville, Minn (S.W., T.L., D.S.); and Philips Healthcare, Hamburg, Germany (B.S.).



To assess if real-time magnetic resonance (MR) imaging-guided radiofrequency (RF) ablation for atrial flutter is feasible in patients.


The study complied with the Declaration of Helsinki and was approved by the local ethics committee. All patients were informed about the investigational nature of the procedures and provided written informed consent. Ten patients (six men; mean age ± standard deviation, 68 years ± 10) with symptomatic atrial flutter underwent isthmus ablation. In all patients, two MR imaging conditional steerable diagnostic and ablation catheters were inserted into the coronary sinus via femoral sheaths and into the right atrium with fluoroscopic guidance. The patients were then transferred to a 1.5-T whole-body MR imager for an ablation procedure, in which the catheters were manipulated by an electrophysiologist by using a commercially available interactive real-time steady-state free precession MR imaging sequence.


All catheters were placed in standard positions successfully. Furthermore, simple programmed stimulation maneuvers were performed. In one of 10 patients, a complete conduction block was performed with MR imaging guidance. In nine of 10 patients, creating only a small number of additional touch-up lesions was necessary to complete the isthmus block with conventional fluoroscopy (median, three lesions; interquartile range, two to four lesions).


Real-time MR imaging-guided placement of multiple catheters is feasible in patients, with subsequent performance of stimulation maneuvers and occasional complete isthmus ablation.

[Indexed for MEDLINE]

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