Format

Send to

Choose Destination
Phys Rev Lett. 2014 Jan 17;112(2):028301. Epub 2014 Jan 13.

Enhanced chemical synthesis at soft interfaces: a universal reaction-adsorption mechanism in microcompartments.

Author information

1
Institut de Sciences et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS UMR 7006, 8 allée Gaspard Monge, F-67083 Strasbourg Cedex, France.
2
Max Planck Institute for Dynamics and Self-organization, Am Fassberg 17, D-37077 Goettingen, Germany.
3
Raindance Technologies France, 8 allée Gaspard Monge, F-67083 Strasbourg Cedex, France.
4
Institut de Sciences et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS UMR 7006, 8 allée Gaspard Monge, F-67083 Strasbourg Cedex, France and Department of Chemistry and Chemical Biology, 12 Oxford Street, Harvard University, Cambridge, Massachussets, Massachusetts 02138, USA.
5
Institut de Sciences et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS UMR 7006, 8 allée Gaspard Monge, F-67083 Strasbourg Cedex, France and Department of Bioengineering, Imperial College London, London SW72AZ, United Kingdom.
6
Institut Charles Sadron, Université de Strasbourg, CNRS UPR 22, 23 rue du Loess, F-67034 Strasbourg Cedex, France.
7
Institut de Sciences et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS UMR 7006, 8 allée Gaspard Monge, F-67083 Strasbourg Cedex, France and École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI ParisTech), CNRS UMR 7084, 10 rue Vauquelin, F-75231 Paris Cedex 05, France.

Abstract

A bimolecular synthetic reaction (imine synthesis) was performed compartmentalized in micrometer-diameter emulsion droplets. The apparent equilibrium constant (Keq) and apparent forward rate constant (k1) were both inversely proportional to the droplet radius. The results are explained by a noncatalytic reaction-adsorption model in which reactants adsorb to the droplet interface with relatively low binding energies of a few kBT, react and diffuse back to the bulk. Reaction thermodynamics is therefore modified by compartmentalization at the mesoscale--without confinement on the molecular scale--leading to a universal mechanism for improving unfavorable reactions.

PMID:
24484045
DOI:
10.1103/PhysRevLett.112.028301
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Physical Society
Loading ...
Support Center