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Traffic. 2014 May;15(5):488-99. doi: 10.1111/tra.12158. Epub 2014 Mar 12.

Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

Abstract

Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen Legionella pneumophila. Here, we demonstrate that SidC proteins are important for early events unique to maturation of vacuoles containing Legionella and discover monoubiquitination of Rab1 as a new SidC-dependent activity. The crystal structure of the SidC N-terminus revealed a novel fold that is important for function and could be involved in Legionella adaptations to evolutionarily divergent host cells it encounters in natural environments.

KEYWORDS:

Rab1 modification; Tethering

PMID:
24483784
PMCID:
PMC4041529
DOI:
10.1111/tra.12158
[Indexed for MEDLINE]
Free PMC Article

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