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Influenza Other Respir Viruses. 2014 May;8(3):384-8. doi: 10.1111/irv.12230. Epub 2014 Jan 31.

Revised and updated nomenclature for highly pathogenic avian influenza A (H5N1) viruses.

Abstract

The divergence of the hemagglutinin gene of A/goose/Guangdong/1/1996-lineage H5N1 viruses during 2011 and 2012 (807 new sequences collected through December 31, 2012) was analyzed by phylogenetic and p-distance methods to define new clades using the pre-established nomenclature system. Eight new clade designations were recommended based on division of clade 1·1 (Mekong River Delta), 2·1·3·2 (Indonesia), 2·2·2 (India/Bangladesh), 2·2·1·1 (Egypt/Israel), and 2·3·2·1 (Asia). A simplification to the previously defined criteria, which adds a letter rather than number to the right-most digit of fifth-order clades, was proposed to facilitate this and future updates.

KEYWORDS:

H5N1; hemagglutinin; highly pathogenic avian influenza; molecular epidemiology; nomenclature; phylogenetics; viral evolution

PMID:
24483237
PMCID:
PMC4181488
DOI:
10.1111/irv.12230
[Indexed for MEDLINE]
Free PMC Article

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