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FEMS Microbiol Rev. 2014 Mar;38(2):254-99. doi: 10.1111/1574-6976.12065. Epub 2014 Mar 3.

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.

Author information

1
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Flanders, Belgium; Department of Molecular Microbiology, VIB, Leuven-Heverlee, Flanders, Belgium.

Abstract

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been elucidated in great detail. This has led to important new concepts and insight into nutrient-controlled cellular regulation. Major highlights include the central role of the Snf1 protein kinase in the glucose repression pathway, galactose induction, the discovery of a G-protein-coupled receptor system, and role of Ras in glucose-induced cAMP signaling, the role of the protein synthesis initiation machinery in general control of nitrogen metabolism, the cyclin-controlled protein kinase Pho85 in phosphate regulation, nitrogen catabolite repression and the nitrogen-sensing target of rapamycin pathway, and the discovery of transporter-like proteins acting as nutrient sensors. In addition, a number of cellular targets, like carbohydrate stores, stress tolerance, and ribosomal gene expression, are controlled by the presence of multiple nutrients. The protein kinase A signaling pathway plays a major role in this general nutrient response. It has led to the discovery of nutrient transceptors (transporter receptors) as nutrient sensors. Major shortcomings in our knowledge are the relationship between rapid and steady-state nutrient signaling, the role of metabolic intermediates in intracellular nutrient sensing, and the identity of the nutrient sensors controlling cellular growth.

KEYWORDS:

G-protein-coupled receptor; Pho85 protein kinase; Ras; Snf1 protein kinase; target of rapamycin; transceptor

PMID:
24483210
PMCID:
PMC4238866
DOI:
10.1111/1574-6976.12065
[Indexed for MEDLINE]
Free PMC Article

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