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Nat Prod Rep. 2014 Mar;31(3):335-55. doi: 10.1039/c3np70092e.

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.

Author information

1
University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, USA. Mooberry@uthscsa.edu.

Abstract

Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer therapy. In this review we cover recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubule-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes. A new potential role for microtubule stabilizers in neurodegenerative diseases is reviewed.

PMID:
24481420
PMCID:
PMC4167679
DOI:
10.1039/c3np70092e
[Indexed for MEDLINE]
Free PMC Article

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