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Br J Cancer. 2014 Mar 4;110(5):1328-33. doi: 10.1038/bjc.2014.17. Epub 2014 Jan 30.

Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study.

Author information

1
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
2
National Office for Cancer Prevention and Control, National Cancer Center, Beijing, China.
3
AARP, Washington, District of Columbia, USA.

Abstract

BACKGROUND:

Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer.

METHODS:

We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492,293 men and women.

RESULTS:

We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer.

CONCLUSION:

Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.

PMID:
24481406
PMCID:
PMC3950867
DOI:
10.1038/bjc.2014.17
[Indexed for MEDLINE]
Free PMC Article

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