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Nat Rev Drug Discov. 2014 Feb;13(2):140-56. doi: 10.1038/nrd4204.

PI3K and cancer: lessons, challenges and opportunities.

Author information

1
Department of Molecular Biology & Biochemistry, and Institute for Immunology, University of California, Irvine, 3242 McGaugh Hall, Irvine, California 92697, USA.
2
Amgen Inc., Thousand Oaks, One Amgen Center Drive, California 91320, USA.

Abstract

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and mammalian target of rapamycin (mTOR) in cancer. However, emerging clinical data show limited single-agent activity of inhibitors targeting PI3K, AKT or mTOR at tolerated doses. One exception is the response to PI3Kδ inhibitors in chronic lymphocytic leukaemia, where a combination of cell-intrinsic and -extrinsic activities drive efficacy. Here, we review key challenges and opportunities for the clinical development of inhibitors targeting the PI3K-AKT-mTOR pathway. Through a greater focus on patient selection, increased understanding of immune modulation and strategic application of rational combinations, it should be possible to realize the potential of this promising class of targeted anticancer agents.

PMID:
24481312
PMCID:
PMC3994981
DOI:
10.1038/nrd4204
[Indexed for MEDLINE]
Free PMC Article

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