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Cardiology. 2014;127(4):247-55. doi: 10.1159/000356951. Epub 2014 Jan 24.

Molecular mechanisms associated with Angiotensin-converting enzyme-inhibitory peptide activity on vascular extracellular matrix remodeling.

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1
Departments of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

OBJECTIVE:

This paper aimed to investigate the molecular mechanisms associated with angiotensin-converting enzyme (ACE)-inhibitory peptide activity involved in vascular extracellular matrix (ECM) remodeling. Therefore, changes in collagen fibers, elastic fibers and laminin were assessed in the left common carotid artery (LCCA).

METHODS:

We selected 10-week-old male spontaneously hypertensive rats to study the expression levels of matrix metalloproteinases (MMPs), transforming growth factor, angiotensin (Ang) II and nuclear factor (NF)-p65 in the wall of carotid arteries.

RESULTS:

Compared to the control group, laminin expression was significantly increased (p < 0.05) in the vascular endothelium of the LAP (a homemade ACE-inhibitory peptide, named by ourselves) group, whereas the percentage of elastic/collagen fibers in the LCCA vascular area was significantly decreased (p < 0.0001) in the LAP group. Immune blots of MMP-2, MMP-9, NF-p65 and AngII were significantly reduced in the LCCA wall in the LAP group.

CONCLUSION:

Vascular ECM remodeling may be related to the inhibitory action of LAP on ECM deposition.

PMID:
24480854
DOI:
10.1159/000356951
[Indexed for MEDLINE]
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