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Curr Opin Virol. 2014 Feb;4:71-7. doi: 10.1016/j.coviro.2013.11.004. Epub 2014 Jan 28.

IFITM proteins-cellular inhibitors of viral entry.

Author information

1
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
2
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
3
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK; MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: pk5@sanger.ac.uk.
4
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: m.marsh@ucl.ac.uk.

Abstract

Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.

PMID:
24480526
DOI:
10.1016/j.coviro.2013.11.004
[Indexed for MEDLINE]

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