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Curr Opin Genet Dev. 2014 Apr;25:38-42. doi: 10.1016/j.gde.2013.11.017. Epub 2014 Jan 28.

Enhancer RNAs: the new molecules of transcription.

Author information

1
Wistar Institute, Philadelphia, PA 19104, USA.
2
Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: Shiekhattar@wistar.org.

Abstract

In the past few years, technological advances in nucleotide sequencing have culminated in a greater understanding of the complexity of the human transcriptome. Notably, the discovery that distal regulatory elements known as enhancers are transcribed and such enhancer-derived transcripts (eRNAs) serve a critical function in transcriptional activation has added a new dimension to transcriptional regulation. Here we review recent insights into the tissue-specific and temporal-specific gene regulation brought about by the discovery of eRNAs.

PMID:
24480293
PMCID:
PMC4484728
DOI:
10.1016/j.gde.2013.11.017
[Indexed for MEDLINE]
Free PMC Article

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