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Int J Pediatr Otorhinolaryngol. 2014 Mar;78(3):561-2. doi: 10.1016/j.ijporl.2013.12.029. Epub 2014 Jan 3.

Obstructive sleep apnea (OSA): a complication of acute infectious mononucleosis infection in a child.

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Division of Pediatric Otolaryngology, Cohen Children's Medical Center, New Hyde Park, NY, United States; Department of Otolaryngology - Head and Neck Surgery, North Shore-LIJ School of Medicine, Hempstead, NY, United States. Electronic address:


Independently, obstructive sleep apnea (OSA) and infectious mononucleosis are not uncommon in the pediatric population, but acute onset of OSA, as a respiratory complication in the setting of acute EBV infection is extremely uncommon. Previous reports of this clinical entity are sparse and from nearly two decades ago. Urgent adenotonsillectomy was commonly advocated. This complication may be managed medically with systemic corticosteroids and non-invasive continuous positive airway pressure (CPAP), and a case is presented to highlight an updated management approach to this rarely encountered clinical problem in children.


Epstein–Barr virus; Infectious mononucleosis; Obstructive sleep apnea; Pediatric

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