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J Family Med Prim Care. 2013 Apr;2(2):206-8. doi: 10.4103/2249-4863.117429.

Liver Abscesses and Hyper IgM Syndrome.

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Pediatric Liver Clinic, B.J. Wadia Hospital for Children, Mumbai, Maharashtra, India.


Hyper IgM (HIGM) syndrome is an immunodeficiency that can lead to liver disease in more than 80% of affected males by an age of 20 years. Hepatitis, sclerosing cholangitis, and hepatocellular malignancies are common among them. We encountered two cases in children of less than 12 years who presented with typical manifestations of liver abscess and were later detected to have a concomitant underlying HIGM syndrome.


Children; hyper IgM; liver abscess

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