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Front Physiol. 2014 Jan 24;5:15. doi: 10.3389/fphys.2014.00015. eCollection 2014.

Atrial fibrillation and microRNAs.

Author information

1
Department of Advanced Biomedical Sciences, "Federico II" University Hospital Naples, Italy ; Department of Translational Medical Sciences, "Federico II" University Hospital Naples, Italy ; Columbia University Medical Center, College of Physicians & Surgeons, New York Presbyterian Hospital - Manhattan New York, NY, USA.
2
Department of Medicine and Surgery, University of Salerno Salerno, Italy ; IRCCS "Multimedica," Milano, Italy.
3
Department of Translational Medical Sciences, "Federico II" University Hospital Naples, Italy.
4
Department of Advanced Biomedical Sciences, "Federico II" University Hospital Naples, Italy.
5
Humanitas Clinical and Research Center Rozzano (Milan), Italy ; University of Milan Milan, Italy.

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

KEYWORDS:

apoptosis; atrial fibrillation; electrical remodeling; electrophysiology; fibrosis; microRNA (miRNA); structural remodeling

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