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J Virol. 2014 Apr;88(8):4595-9. doi: 10.1128/JVI.03190-13. Epub 2014 Jan 29.

Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models.

Author information

1
Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.

Abstract

We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza.

PMID:
24478425
PMCID:
PMC3993775
DOI:
10.1128/JVI.03190-13
[Indexed for MEDLINE]
Free PMC Article

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