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JAMA Dermatol. 2014 Mar;150(3):288-90. doi: 10.1001/jamadermatol.2013.8705.

Retreatment with omalizumab results in rapid remission in chronic spontaneous and inducible urticaria.

Author information

1
Department of Dermatology, Venerology, and Allergology, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Abstract

IMPORTANCE:

Omalizumab has emerged as a novel and effective treatment option for patients with antihistamine-resistant chronic urticaria. It is unclear whether patients with recurrent urticaria symptoms after discontinuation of omalizumab treatment can benefit from retreatment.

OBJECTIVE:

To assess the response of patients with chronic urticaria who receive omalizumab retreatment.

DESIGN, SETTING, AND PARTICIPANTS:

Retrospective analyses were conducted of outpatients treated at an urticaria specialist center of a university hospital. Participants included 25 consecutive patients (aged 18-74 years; 18 women) with chronic spontaneous urticaria, chronic inducible urticaria, or both who showed complete response to omalizumab treatment, experienced relapse after discontinuation of treatment, and received retreatment with omalizumab.

INTERVENTIONS:

Subcutaneous treatment with omalizumab (150-600 mg/mo).

MAIN OUTCOMES AND MEASURES:

Response after retreatment was assessed by the urticaria activity score in patients with chronic spontaneous urticaria and by trigger threshold testing (in patients with cold urticaria or symptomatic dermographism) and/or a carefully determined history (in patients with cholinergic urticaria, solar urticaria, or pressure urticaria). Adverse events were documented.

RESULTS:

All patients experienced complete response after retreatment. None of the patients reported relevant adverse events during omalizumab treatment and retreatment.

CONCLUSIONS AND RELEVANCE:

Omalizumab retreatment is effective and safe in patients with chronic urticaria who have benefited from initial omalizumab treatment.

PMID:
24477320
DOI:
10.1001/jamadermatol.2013.8705
[Indexed for MEDLINE]

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