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Public Health Nutr. 2014 Apr;17(4):833-43. doi: 10.1017/S1368980013003492. Epub 2014 Jan 10.

Is vitamin D status associated with open-angle glaucoma? A cross-sectional study from South Korea.

Author information

1
1 Department of Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
2
3 Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

OBJECTIVE:

Open-angle glaucoma (OAG) is one of the major chronic diseases involving the optic nerve. However, little is known about the association between vitamin D and OAG. The present study was conducted to test the hypothesis that lower vitamin D status is associated with greater prevalence of OAG.

DESIGN:

Cross-sectional study. Multivariable logistic regression was performed to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and OAG after adjusting for traditional potential confounders. OAG was defined by the criteria of the International Society for Geographical and Epidemiological Ophthalmology.

SETTING:

The Fifth Korean National Health and Nutrition Examination Survey conducted in 2010-2011.

SUBJECTS:

Six thousand and ninety-four adult participants randomly selected from 192 surveys in 131 locations in South Korea.

RESULTS:

Multivariable-adjusted odds ratios of OAG across quintiles of decreasing 25(OH)D were 1.26, 1.00 (reference), 1.31, 1.36 and 1.69 (P for quadratic trend <0.01). The odds ratio for the lowest 25(OH)D quintile was significantly higher than that for the second quintile (P < 0.01). In addition, we discovered that the predictors for worsening of OAG, such as intraocular pressure or vertical and horizontal cup-to-disc ratios, had a significant relationship with 25(OH)D level.

CONCLUSIONS:

There was a reverse J-shaped association between 25(OH)D levels and the risk of OAG, with significantly elevated risk at lower 25(OH)D. The findings of this research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG. To our knowledge, the present study is the first one that shows an association between vitamin D status and OAG.

PMID:
24476947
DOI:
10.1017/S1368980013003492
[Indexed for MEDLINE]

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