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Arch Pathol Lab Med. 2014 Feb;138(2):182-8. doi: 10.5858/arpa.2012-0551-OA.

Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas.

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From the Departments of Pathology (Drs Mete and Asa) and Medicine (Dr Ezzat), University Health Network, Toronto, Ontario, Canada; the Department of Pathology, Tufts Medical Center, Boston, Massachusetts (Dr Tischler); the Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands (Dr de Krijger); the Department of Molecular and Cellular Pathology, The University of Queensland, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia (Dr McNicol); the Institute of Clinical Chemistry and Laboratory Medicine and Department of Medicine III, University of Dresden, Dresden, Germany (Dr Eisenhofer); and the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institutes of Health, Bethesda, Maryland (Dr Pacak).


During the last decade there have been revolutionary breakthroughs in understanding the biology of pheochromocytomas and extra-adrenal paragangliomas. Discoveries of new susceptibility genes and genotype-phenotype correlations have led to the realization that appropriate patient care requires a complete integration of clinical, genetic, biochemical, imaging, and pathology findings. Clinical practice has in many cases not kept pace with the rate of discovery, underscoring a need for updated procedures for evaluation of patient specimens and reporting of data. We therefore propose a new synoptic reporting approach for pheochromocytomas and extra-adrenal paragangliomas that will provide clear and uniform information to pathologists and clinicians, in order to advance the diagnosis of these neoplasms and optimize patient care.

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