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J Nephropathol. 2013 Oct;2(4):254-7. doi: 10.12860/JNP.2013.40. Epub 2013 Oct 1.

Association of serum calcium with level of blood pressure in type 2 diabetic patients.

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Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.



Hypertension and diabetes are two common diseases and they affect the same major target organs.


In this study, we sought to investigate the probable association of serum calcium with levels of systolic and blood pressure in a group of type 2 diabetic (T2D) patients.


A total of 60 patients with T2D were enrolled to the study. To determine serum creatinine, calcium and hemoglobin A1c (HbA1c), venous blood samples were obtained in the fasting state.


Among 60 participants, 56.7% were female. Mean of ages was 57±8.3 years. Mean of systolic and diastolic blood pressure were 133±13 mmHg and 84±7.4 mmHg, respectively. Mean of serum calcium was 9.0±0.4 mg/dl. In this study, there was no significant difference of serum calcium and HbA1c between males and females. A significant inverse correlation of serum calcium with level of diastolic blood pressure (r= -0.261, p=0.046) was seen (adjusted for duration of diabetes). Moreover, a negative correlation of systolic blood pressure with level of serum calcium was existed, however, this correlation was not significant (r= -0.232, p=0.080) [adjusted for duration of diabetes].


We found a significant inverse correlation of serum calcium with level of diastolic blood pressure. We propose to more attention to serum calcium during the treatment of hypertension in diabetic patients.


Calcium; Hypertension; Type 2 diabetes

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