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J Nephropathol. 2013 Oct;2(4):217-33. doi: 10.12860/JNP.2013.36. Epub 2013 Jul 1.

Hepatitis C virus infection in nephrology patients.

Author information

1
Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France ; INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France ; Université Paul Sabatier, Toulouse, France.
2
INSERM U1043, IFR-BMT, CHU Purpan, Toulouse, France ; Université Paul Sabatier, Toulouse, France ; Department of Virology, CHU Purpan, Toulouse, France.

Abstract

CONTEXT:

Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations.

EVIDENCE ACQUISITIONS:

Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

RESULTS:

Herein, we provide an overview of renal diseases related to HCV and their therapies, as well as the treatment options available for HCV (+)/RNA (+) dialysis patients. We will not mention, however, HCV infection-related complications in the post-kidney transplantation setting.

CONCLUSIONS:

Extra-hepatic manifestations of HCV infection include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys.

KEYWORDS:

Glomerulonephritis; Hepatitis C; Membranoproliferative glomerulonephritis; Renal transplantation

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