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J Nephropathol. 2013 Jan;2(1):67-70. doi: 10.5812/nephropathol.9092. Epub 2013 Jan 1.

Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment.

Author information

1
Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Abstract

BACKGROUND:

Hypertension (HTN) is a very common disorder with a substantial impact on public health because of its complications.

OBJECTIVES:

To study the association of serum lipoprotein(a) [Lp(a)] elevation with essential hypertension (eHTN).

PATIENTS AND METHODS:

This study was conducted on a group of essential hypertensive patients. Laboratory exams consisting of serum creatinine and Lp(a) were measured.

RESULTS:

Ninety five essential hypertensive patients were enrolled to the study. Serum LP (a) in patients was 46.5±20. In patients an inverse correlation between serum Lp(a) andcreatinine clearance was seen (r = -0.175 p<0.05). There was a significant correlation between serum Lp(a) and age (r =0.191 p<0.05) or duration of HTN (known duration of hypertension period) (r =0.362 p<0.05).

CONCLUSIONS:

Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.

KEYWORDS:

Essential hypertension; Lipoprotein (a); Renal failure

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