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J Nephropathol. 2012 Apr;1(1):17-22. doi: 10.5812/jnp.5. Epub 2012 Apr 5.

Turmeric: Reemerging of a neglected Asian traditional remedy.

Author information

1
Shiraz Nephro-Urology Research Center and Department of Nephrology, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

CONTEXT:

Turmeric (Curcuma longa) is a wild plant of the ginger family native to tropical South Asia.

EVIDENCE ACQUISITIONS:

Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

RESULTS:

Emerging evidence indicate that turmeric/curcumin inhibits cytokines and TGF-β production. From the various factors involved in the genesis of chronic kidney disease and pathogenesis of primary and secondary glomerulonehritis, TGF-β has emerged as a key factor in the cascade of events. Leading to glomerulosclerosis, tubulointerstitial fibrosis and end-stage renal disease.

CONCLUSIONS:

considering the inhibitory effect of turmeric/curcumin on cytokines and TGF-β, it seems wise to assume that supplementary turmeric/curcumin might be a candidate remedy for chronic kidney disease and possibly prevention of subsequent end stage renal disease.

KEYWORDS:

Chronic kidney disease; Curcumin; End stage renal disease; Turmeric

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