Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Pulmonol. 2014 Nov;49(11):1145-52. doi: 10.1002/ppul.22972. Epub 2014 Jan 29.

Salivary biomarkers of obstructive sleep apnea syndrome in children.

Author information

1
Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, Rome, Italy.

Abstract

OBJECTIVES:

The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed between the salivary biomarker concentrations and the PSG variables characterizing the OSA severity.

METHODS:

We studied 27 consecutive OSA patients (13 mild OSA; 14 MS OSA) and seven healthy children who were enrolled as controls by collecting salivary samples and measuring cortisol and α-amylase levels using enzyme-linked bioassays.

RESULTS:

Compared with controls, both mild and MS OSA children showed: (1) increased salivary cortisol diurnal production, (2) maintenance of the physiological circadian activity of the HPA axis, and (3) no changes in α-amylase diurnal trajectory and production. In addition, morning salivary cortisol concentrations was negatively associated with the disease severity in the MS OSA group.

CONCLUSIONS:

OSA is associated with dysregulation of the HPA axis activity in children, the latter potentially underlying some of the adverse consequences of the disease.

KEYWORDS:

AUC; OSA; children; salivary cortisol; salivary α-amylase

PMID:
24474530
DOI:
10.1002/ppul.22972
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center