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Acta Cir Bras. 2014 Jan;29(1):30-7. doi: 10.1590/S0102-86502014000100005.

Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats.

Author information

1
Herminio Ometto University Center, School of Pharmacy, ArarasSP, Brazil.
2
Herminio Ometto University Center, ArarasSP, Brazil.
3
State University of Campinas, Multidisciplinary Center for Chemical, Biological and Agricultural, Phytochemistry Division, CampinasSP, Brazil.

Abstract

PURPOSE:

To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats.

METHODS:

Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4.

RESULTS:

Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata.

CONCLUSION:

The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.

PMID:
24474175
DOI:
10.1590/S0102-86502014000100005
[Indexed for MEDLINE]
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