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An Bras Dermatol. 2013 Nov-Dec;88(6):1019-21. doi: 10.1590/abd1806-4841.20132180.

Endonyx toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye.

Author information

1
Center for Infectious Diseases Research, Clemente Faria University Hospital, Montes Claros State University, Department of Clinical Medicine, Montes ClarosMG, Brazil, Master in Health Sciences - Professor of Dermatology and Research Professor, Department of Clinical Medicine, Center for Infectious Diseases Research -Clemente Faria University Hospital - Montes Claros State University (HUCF - UNIMONTES) - Montes Claros (MG), Brazil.
2
Program in Health Sciences, Montes Claros State University, Montes ClarosMG, Brazil, Specialist, student in the Postgraduate Program in Health Sciences and Designated Professor - Montes Claros State University (UNIMONTES) - Montes Claros (MG), Brazil.
3
Health Sciences Postgraduate Program, Montes Claros State University, Montes ClarosMG, Brazil, Post-Doctorate in Parasitology - Professor in the Health Sciences Postgraduate Program of the Montes Claros State University (UNIMONTES) - Montes Claros (MG), Brazil.

Abstract

This study shows the effectiveness of photodynamic therapy based on methylene blue dye for the treatment of endonyx toenail onychomycosis. Four patients with endonyx onychomycosis caused by Trichophyton rubrum were treated with 2% methylene blue aqueous solution irradiated with light emission diode at 630 nm and an energy density of 36 J/cm2 for 6 months at 2-week intervals. The preliminary study showed the effectiveness of this therapy in the treatment of endonyx onychomycosis, and also indicated that the disease can be caused by T. rubrum.

PMID:
24474123
PMCID:
PMC3900365
DOI:
10.1590/abd1806-4841.20132180
[Indexed for MEDLINE]
Free PMC Article

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