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Brain Tumor Pathol. 2014 Jul;31(3):177-81. doi: 10.1007/s10014-014-0176-2. Epub 2014 Jan 29.

Case of primary diffuse leptomeningeal gliomatosis.

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1
Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan, cozy5552@fc.miyazaki-u.ac.jp.

Abstract

Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease characterized by diffuse infiltration of the leptomeninges by neoplastic glial cells without evidence of tumor in the brain parenchyma or spinal cord. We report a 60-year-old man with PDLG. He suffered transient right hemiparesis and generalized seizures. MRI showed diffuse leptomeningeal thickening and enhancement throughout the brain and spinal cord without any intraaxial involvement. Biopsy resulted in a diagnosis of glioblastoma with methylated MGMT promoter and wild-type IDH1. He underwent craniospinal radiotherapy and temozolomide treatment but despite concomitant adjuvant therapy he died 8 months after initial presentation.

PMID:
24473978
DOI:
10.1007/s10014-014-0176-2
[Indexed for MEDLINE]
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