Send to

Choose Destination
Neurochem Res. 2014 Oct;39(10):1942-7. doi: 10.1007/s11064-014-1245-y. Epub 2014 Jan 29.

Muscimol as an ionotropic GABA receptor agonist.

Author information

Adrien Albert Laboratory of Medicinal Chemistry, School of Medical Sciences (Pharmacology), The University of Sydney, Sydney, NSW, 2006, Australia,


Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(®)) and 4-PIOL.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center