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Neurochem Res. 2014 Oct;39(10):1942-7. doi: 10.1007/s11064-014-1245-y. Epub 2014 Jan 29.

Muscimol as an ionotropic GABA receptor agonist.

Author information

1
Adrien Albert Laboratory of Medicinal Chemistry, School of Medical Sciences (Pharmacology), The University of Sydney, Sydney, NSW, 2006, Australia, grahamj@mail.usyd.edu.au.

Abstract

Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(®)) and 4-PIOL.

PMID:
24473816
DOI:
10.1007/s11064-014-1245-y
[Indexed for MEDLINE]

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