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Eur J Clin Nutr. 2014 Mar;68(3):350-7. doi: 10.1038/ejcn.2013.290. Epub 2014 Jan 29.

Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial.

Author information

1
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
2
Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
3
Department of Statistics, USBE, Umeå University, Umeå, Sweden.
4
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
5
1] Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden [2] Department of Food and Nutrition, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND/OBJECTIVES:

Short-term studies have suggested beneficial effects of a Palaeolithic-type diet (PD) on body weight and metabolic balance. We now report the long-term effects of a PD on anthropometric measurements and metabolic balance in obese postmenopausal women, in comparison with a diet according to the Nordic Nutrition Recommendations (NNR).

SUBJECTS/METHODS:

Seventy obese postmenopausal women (mean age 60 years, body mass index 33 kg/m(2)) were assigned to an ad libitum PD or NNR diet in a 2-year randomized controlled trial. The primary outcome was change in fat mass as measured by dual-energy X-ray absorptiometry.

RESULTS:

Both groups significantly decreased total fat mass at 6 months (-6.5 and-2.6 kg) and 24 months (-4.6 and-2.9 kg), with a more pronounced fat loss in the PD group at 6 months (P<0.001) but not at 24 months (P=0.095). Waist circumference and sagittal diameter also decreased in both the groups, with a more pronounced decrease in the PD group at 6 months (-11.1 vs-5.8 cm, P=0.001 and-3.7 vs-2.0 cm, P<0.001, respectively). Triglyceride levels decreased significantly more at 6 and 24 months in the PD group than in the NNR group (P<0.001 and P=0.004). Nitrogen excretion did not differ between the groups.

CONCLUSIONS:

A PD has greater beneficial effects vs an NNR diet regarding fat mass, abdominal obesity and triglyceride levels in obese postmenopausal women; effects not sustained for anthropometric measurements at 24 months. Adherence to protein intake was poor in the PD group. The long-term consequences of these changes remain to be studied.

PMID:
24473459
PMCID:
PMC4216932
DOI:
10.1038/ejcn.2013.290
[Indexed for MEDLINE]
Free PMC Article
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