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Nat Genet. 2014 Feb;46(2):96-8. doi: 10.1038/ng.2879.

A RAG driver on the road to pediatric ALL.

Author information

  • 1Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands, and with the Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Abstract

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

PMID:
24473322
DOI:
10.1038/ng.2879
[PubMed - indexed for MEDLINE]
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