Format

Send to

Choose Destination
See comment in PubMed Commons below
J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):517-21. doi: 10.1038/jes.2013.95. Epub 2014 Jan 29.

Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women.

Author information

1
1] Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA [2] Department of food, water and cosmetics, Norwegian Institute of Public Health, Oslo, Norway.
2
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
3
1] Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA [2] Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
4
Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
5
Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA.
6
Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway.
7
Department of Childhood, Development and Cultural diversity, Norwegian Institute of Public Health, Oslo, Norway.
8
Department of Genetics, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
9
Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.

Abstract

Triclosan (TCS) is a synthetic antibacterial chemical that is used in personal care products and is measurable in urine. Urinary TCS has been associated with allergy in children in Norway and the United States. A reasonable degree of temporal reliability of TCS urinary concentrations has been reported among US children as well as for Puerto Rican pregnant women. We examined the reliability of TCS measures in urine among Norwegian pregnant women. TCS was measured in spot urine samples collected in gestational weeks 17, 23, and 29 from 45 women in The Norwegian Mother and Child Cohort Study (MoBa) enrolled in 2007 and 2008. Spearman's rank correlation coefficient (rs) and intraclass correlation coefficient (ICC) statistics were calculated. Fifty-six percent of the 45 women had a least one sample with a value above the method limit of detection (2.3 μg/l). The correlation coefficients were 0.61 for TCS concentrations at 17 and 23 weeks and 0.49 for concentrations at 17 and 29 weeks. For the three time points, the ICC was 0.49. The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.

PMID:
24472755
PMCID:
PMC4115053
DOI:
10.1038/jes.2013.95
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center