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Prev Med. 2014 May;62:1-7. doi: 10.1016/j.ypmed.2014.01.015. Epub 2014 Jan 25.

Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers.

Author information

1
School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia; National Centre for Immunization Research and Surveillance, The Children's Hospital at Westmead, Sydney, Australia.
2
The Beijing Center for Disease Prevention and Control, Beijing, China.
3
School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia.
4
School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia. Electronic address: a.moa@unsw.edu.au.
5
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, Westmead Hospital and University of Sydney, Australia.

Erratum in

  • Prev Med. 2014 Dec;69:165.

Abstract

OBJECTIVE:

We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs).

METHODS:

A cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR).

RESULTS:

The rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm.

CONCLUSIONS:

N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.

KEYWORDS:

Bacterial colonization; Healthcare workers; Hospitals; N95 respirators and medical masks

PMID:
24472436
DOI:
10.1016/j.ypmed.2014.01.015
[Indexed for MEDLINE]
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