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J Am Acad Dermatol. 2014 Apr;70(4):788-792. doi: 10.1016/j.jaad.2013.12.005. Epub 2014 Jan 25.

A review of toxicity from topical salicylic acid preparations.

Author information

1
Beth Israel Medical Center, Mount Sinai Health System, New York, New York; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
2
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: jacob.levitt@mssm.edu.

Abstract

Topical salicylic acid is often used in dermatologic conditions because of its keratolytic, bacteriostatic, fungicidal, and photoprotective properties. The bioavailability of salicylic acid differs depending on the vehicle used and pH of transcellular fluids. Although rare, salicylic acid toxicity (salicylism) can occur from topical application. Physicians should be mindful of the potential for salicylism or even death from topically applied salicylic acid.

KEYWORDS:

ichthyosis; psoriasis; salicylic acid; salicylism; skin absorption; topical; toxicity

PMID:
24472429
DOI:
10.1016/j.jaad.2013.12.005
[Indexed for MEDLINE]

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