Format

Send to

Choose Destination
See comment in PubMed Commons below
Physiol Behav. 2014 Mar 29;127:37-44. doi: 10.1016/j.physbeh.2014.01.004. Epub 2014 Jan 25.

Effects of a breakfast spread out over time on the food intake at lunch and the hormonal responses in obese men.

Author information

1
Centre de Recherche de l'Institut Paul Bocuse, Château du Vivier, 69130 Ecully, France; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France; Centre Européen pour la Nutrition & la Santé (CENS), Lyon, France. Electronic address: xallirot@bculinary.com.
2
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France; Centre Européen pour la Nutrition & la Santé (CENS), Lyon, France; Faculté de Médecine de Maïeutique Lyon Sud, Charles Mérieux-F69495 Pierre-Bénite, CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, France.
3
Centre de Recherche de l'Institut Paul Bocuse, Château du Vivier, 69130 Ecully, France; Centre Européen pour la Nutrition & la Santé (CENS), Lyon, France.
4
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France; Pôle Recherche, CHU Grenoble - Inserm U1055-Bioénergétique, Université J. Fourier, Grenoble, France.
5
Faculté de Médecine de Maïeutique Lyon Sud, Charles Mérieux-F69495 Pierre-Bénite, CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, France.
6
Centre Européen pour la Nutrition & la Santé (CENS), Lyon, France; Faculté de Médecine de Maïeutique Lyon Sud, Charles Mérieux-F69495 Pierre-Bénite, CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, France.
7
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France; Centre Européen pour la Nutrition & la Santé (CENS), Lyon, France.

Abstract

The effects of frequent eating on health and particularly on appetite and metabolism are unclear. We have previously shown that frequent eating decreased appetite and energy intake at the subsequent meal in lean men. In the present study, we tested the same pattern in obese subjects. Seventeen obese men participated in: (i) two sessions consisting of a breakfast consumed in one eating episode at T0 (F1), or in four isocaloric eating episodes at T0, T60, T120, and T180min (F4), followed by an ad libitum buffet (T240) in an experimental restaurant. Subjects rated their appetite throughout the sessions. (ii) two sessions consisting of the same breakfasts F1 and F4 in a Clinical Centre, followed by a standardized meal. Blood sampling was performed to study ghrelin, glucagon-like peptide-1 (GLP-1), and metabolic kinetics. Indirect calorimetry measurements were performed. After F4, at T240min, ghrelin concentration (P=0.03) and hunger ratings (P<0.001) were lower while GLP-1 concentration (P=0.006) and satiety ratings (P=0.02) were higher. In F4, subjects consumed at the buffet, less food in grams (P=0.04) and less energy from low energy dense foods (P=0.01), but total energy intakes were not different between conditions. In F4, the area under the curve was lower for insulin (P=0.02) and non-esterified fatty acids (NEFA) (P=0.03). Diet induced thermogenesis was reduced in F4 (P=0.03) between T0 and T240. Even if subjective and physiological data suggest a beneficial effect of frequent eating on appetite in obese men, no effect was demonstrated on energy intake. Moreover, the decrease in diet induced thermogenesis and lipolysis, reflected by NEFA profiles, could be deleterious on energy balance in the long run.

KEYWORDS:

Appetite control; Eating frequency; Food intake; Ghrelin; Glucagon-like peptide-1; Satiety

PMID:
24472321
DOI:
10.1016/j.physbeh.2014.01.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center