Format

Send to

Choose Destination
Nanomedicine (Lond). 2014 Jul;9(9):1353-62. doi: 10.2217/nnm.13.138. Epub 2014 Jan 7.

Large pore mesoporous silica induced weight loss in obese mice.

Author information

1
Nanotechnology & Functional Materials, Department of Engineering Sciences, Uppsala University, Box 534, 751 21, Uppsala, Sweden.

Abstract

BACKGROUND:

There is a need for medical treatments to curb the rising rate of obesity. Weight reduction is correlated with a decrease in associated risk factors and cholesterol levels in humans. Amorphous silica particles have been found to exert a hypocholesterolemic effect in humans, making them popular dietary additives.

AIM:

To investigate the effect of mesoporous silica, which possess sharp pore size distributions, on: weight loss, cholesterol, triglycerides and glucose blood levels in obese mice.

MATERIALS & METHODS:

Mesoporous silicas with differing pore size were mixed in the high-fat diet of obese mice.

RESULTS:

Animals receiving large pore mesoporous silica with a high-fat diet show a significant reduction in body weight and fat composition, with no observable negative effects.

CONCLUSION:

Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.

KEYWORDS:

body fat; body weight; cholesterol; high-fat diet; mesoporous silica; obesity

PMID:
24471500
DOI:
10.2217/nnm.13.138
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center