Format

Send to

Choose Destination
Met Ions Life Sci. 2013;13:199-227. doi: 10.1007/978-94-007-7500-8_7.

Manganese in health and disease.

Author information

1
Biochemistry Graduation Program, Universidade Federal do Pampa, Uruguaiana, Rio Grande do Sul, Brazil, avilads1@gmail.com.

Abstract

Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

PMID:
24470093
PMCID:
PMC6589086
DOI:
10.1007/978-94-007-7500-8_7
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center