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Curr Opin Biotechnol. 2014 Apr;26:141-7. doi: 10.1016/j.copbio.2013.12.012. Epub 2014 Jan 28.

Probiotics tailored to the infant: a window of opportunity.

Author information

1
Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, Switzerland.
2
Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zürich, Schmelzbergstrasse 7, Zürich CH-8092, Switzerland. Electronic address: christophe.lacroix@hest.ethz.ch.

Abstract

Initial neonatal gut colonization is a crucial stage for developing a healthy physiology, beneficially influenced by breast-feeding. Breast milk has been shown not only to provide nutrients and bioactive immunological compounds, but also commensal bacteria, including gut-associated anaerobic bacteria such as Bifidobacterium species. Infant formulas are increasingly supplemented with probiotic bacteria despite uncertainties regarding their efficacy, and lack of mechanistic understanding. Breast milk may be a valuable source of such bacteria which, upon validation of their mechanism of action, might open a window of opportunity for developing probiotic-supplemented infant formula with proven efficacy.

PMID:
24469588
DOI:
10.1016/j.copbio.2013.12.012
[Indexed for MEDLINE]

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