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J Basic Clin Physiol Pharmacol. 2014 Jan 27:1-7. doi: 10.1515/jbcpp-2013-0010. [Epub ahead of print]

Antibacterial activity of the body wall extracts of sea cucumber (Invertebrata; Echinodermata) on infectious oral streptococci.



The present study was carried out to test the antibacterial effect of the body wall of the sea cucumber Holothuria leucospilota Brandt on Streptococcus mutans and Streptococcus salivarius.


After sampling sea cucumbers from the Persian Gulf, different extractions were prepared. Then, aqueous, phosphate-buffered saline (PBS, pH 7.8), chloroform, hexane and methanolic extracts from sea cucumber body wall were screened for antibacterial activity against pathogenic bacteria S. mutans and S. salivarius using the disk diffusion method.


The PBS extract did not show any antibacterial or inhibitory activity; the chloroform extract, however, demonstrated high levels of antibacterial activity against S. salivarius while exhibiting low levels of activity against S. mutans. The hexane and methanolic extracts were found to show no antibacterial activity against S. mutans, but exhibited antibacterial activity against S. salivarius.


In conclusion, the results demonstrated the possibility of utilizing sea cucumbers as a cheap source of potential antibacterial agents and for treating odontogenic diseases.


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