Format

Send to

Choose Destination
Curr Opin Biotechnol. 2014 Aug;28:88-95. doi: 10.1016/j.copbio.2013.12.011. Epub 2014 Jan 25.

Functional DNA nanomaterials for sensing and imaging in living cells.

Author information

1
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
2
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address: yi-lu@illinois.edu.

Abstract

Recent developments in integrating high selectivity of functional DNA, such as DNAzymes and aptamers, with efficient DNA delivery into cells by gold nanoparticles or superior near-infrared optical properties of upconversion nanoparticles are reviewed. Their applications in sensing and imaging small organic metabolites, toxins, metal ions, pH, DNA, RNA, proteins, and pathogens are summarized. The advantages and future directions of these functional DNA materials are discussed.

PMID:
24468446
PMCID:
PMC4110194
DOI:
10.1016/j.copbio.2013.12.011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center