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J Infect. 2014 Jun;68(6):527-33. doi: 10.1016/j.jinf.2014.01.004. Epub 2014 Jan 25.

Serious long-term health consequences of Q-fever and Legionnaires' disease.

Author information

1
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: joris.vanloenhout@radboudumc.nl.
2
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: hhmmvantiel@gmail.com.
3
Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, 's-Hertogenbosch, The Netherlands. Electronic address: j.vd.heuvel@ggdhvb.nl.
4
Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: jan.vercoulen@radboudumc.nl.
5
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: hans.bor@radboudumc.nl.
6
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: koos.vandervelden@radboudumc.nl.
7
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands. Electronic address: john.paget@radboudumc.nl.
8
Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: jeannine.hautvast@radboudumc.nl.

Abstract

BACKGROUND:

We assessed and compared the long-term health status of Q-fever patients and patients with Legionnaires' disease.

METHODS:

Q-fever patients and patients with Legionnaires' disease fulfilling the Dutch notification criteria filled out a questionnaire at one year after onset of illness. The proportion of patients with an abnormal score was calculated for 12 health status subdomains and mean scores for the most relevant subdomains were compared between the patient groups.

RESULTS:

We included 309 Q-fever patients and 190 patients with Legionnaires' disease in the study. A large proportion of the two patient groups was negatively affected on many of the subdomains, especially 'Fatigue', 'General Quality of Life' and 'Role Physical'. We assessed health status of the patient groups using a multivariate regression analysis and found no significant difference for 'Fatigue' and 'General Quality of Life'. Only for the subdomain 'Role Physical', Q-fever patients scored significantly worse compared to patients with Legionnaires' disease.

CONCLUSIONS:

Many Q-fever patients and patients with Legionnaires' disease suffer from a severely affected health status on one or more subdomains at one year after onset of illness. We recommend additional support for a large proportion of both patient groups during the first year after onset of illness.

KEYWORDS:

Fatigue; Health status; Legionnaires' disease; Q-fever; Quality of life

PMID:
24468188
DOI:
10.1016/j.jinf.2014.01.004
[Indexed for MEDLINE]

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