Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Biophys Res Commun. 2014 Feb 14;444(3):387-90. doi: 10.1016/j.bbrc.2014.01.062. Epub 2014 Jan 24.

P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.

Author information

1
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
2
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. Electronic address: songhuazhan.sg@gmail.com.

Abstract

MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion. Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2. Furthermore, mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells and migration and invasion of Rat1 fibroblasts. These results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research.

KEYWORDS:

Acetylation; Cell growth; MTA2; Migration; P300

PMID:
24468085
DOI:
10.1016/j.bbrc.2014.01.062
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center