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Biochemistry. 2014 Feb 11;53(5):810-20. doi: 10.1021/bi401596q. Epub 2014 Jan 27.

Integrin cytoplasmic tail interactions.

Author information

1
Department of Cell Biology and ‡Department of Pharmacology, Yale University School of Medicine , 333 Cedar Street, New Haven, Connecticut 06520, United States.

Abstract

Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling.

PMID:
24467163
PMCID:
PMC3985435
DOI:
10.1021/bi401596q
[Indexed for MEDLINE]
Free PMC Article

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