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Biochem Pharmacol. 1987 Nov 15;36(22):3809-13.

Effect of PGI2 on transcellular transport of fluorescein dextran through an arterial endothelial monolayer.

Author information

1
Department of Microbiology and Molecular Pathology, Teikyo University, Kanagawa, Japan.

Abstract

The effects of prostacyclin (PGI2) and stable derivatives of PGI2, such as isocarbacyclin (PGI2 deriv. (A] and isocarbacyclin methyl ester (PGI2 deriv. (B)), on junctional transport of fluorescein dextran (FD) through cultured porcine arterial endothelial cells were investigated. These PGI2S inhibited the transcellular transport dose-dependently. After the elimination of PGI2, its inhibitory effect persisted for at least 1 hr. A good correlation was found between increase of cAMP and the potency of inhibition. Increase of cAMP after PGI2 treatment seemed to be involved in the inhibition of FD transport.

PMID:
2446625
DOI:
10.1016/0006-2952(87)90442-4
[Indexed for MEDLINE]

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